{"id":134,"date":"2023-10-16T08:45:18","date_gmt":"2023-10-16T07:45:18","guid":{"rendered":"https:\/\/ccb.flaus.net\/ccb2\/?page_id=134"},"modified":"2026-04-10T22:43:26","modified_gmt":"2026-04-10T21:43:26","slug":"carty","status":"publish","type":"page","link":"https:\/\/chromosome.ie\/gae\/groups\/carty\/","title":{"rendered":"Michael Carty"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Michael-Carty-3.jpg\" alt=\"\" class=\"wp-image-363\" style=\"width:150px\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Michael-Carty-3.jpg 512w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Michael-Carty-3-300x300.jpg 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Michael-Carty-3-150x150.jpg 150w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/figure>\n<\/div>\n\n\n<p><strong>Dr Michael Carty<\/strong><\/p>\n\n\n\n<p>Senior Lecturer in Biochemistry<br>michael.carty@universityofgalway.ie<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Research interests<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Human DNA damage response to UV radiation and cisplatin damage<\/li>\n\n\n\n<li>DNA polymerase eta in translesion synthesis<\/li>\n\n\n\n<li>Novel anti-cancer agents<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Research overview<\/h4>\n\n\n\n<p class=\"has-text-align-justify\">Our main research interest is the molecular basis of the response of human cells to DNA damaging agents. This includes investigation of DNA damage response pathways in primary normal human melanocytes exposed to long-wavelength UVA light, as well as mechanistic studies of the response to human cells to DNA damage-induced replication arrest. <\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-justify\">We focus on the role of the human&nbsp;<em>POLH<\/em>&nbsp;gene product DNA polymerase eta in translesion synthesis, and on the activation of downstream damage signalling pathways, in particular PIK kinase-mediated phosphorylation of replication protein A (RPA). <\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"475\" height=\"365\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/MC-Pol-eta-GFP.png\" alt=\"\" class=\"wp-image-1522\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/MC-Pol-eta-GFP.png 475w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/MC-Pol-eta-GFP-300x231.png 300w\" sizes=\"auto, (max-width: 475px) 100vw, 475px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-justify\">The response of human mesenchymal stem cells to platinum-based chemotherapeutic agents or ionising radiation has been investigated in collaboration with the Regenerative Medicine Institute at NUI, Galway.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">Mechanistic studies of the response to human cells to DNA damage-induced replication arrest focus on the role of the human POLH gene product DNA polymerase eta in translesion synthesis, and on the activation of downstream damage signalling pathways, in particular PIK kinase-mediated phosphorylation of replication protein A (RPA).<\/p>\n\n\n\n<p class=\"has-text-align-justify\">We have an ongoing collaboration with Dr. F. Aldabbagh, School of Chemistry, NUI, Galway to characterise the effects of novel derivatives of the anti-cancer drug mitomycin C on normal and cancer cell lines.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<p class=\"has-white-color has-text-color has-link-color wp-elements-01358db7b1df820252a11e2d847dd7b9\">S<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"566\" height=\"340\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/MP-Cisplatin.png\" alt=\"\" class=\"wp-image-1524\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/MP-Cisplatin.png 566w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/MP-Cisplatin-300x180.png 300w\" sizes=\"auto, (max-width: 566px) 100vw, 566px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\">\n<h4 class=\"wp-block-heading\">Keywords<\/h4>\n\n\n\n<p>Cancer, UV radiation, DNA damage response,  cisplatin, translesion synthesis, Pol eta, POLH, PIK Kinase, Fusion Genes, Chemotherapy, Therapeutics<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Key Research techniques<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tissue Culture<\/li>\n\n\n\n<li>Molecular Biology<\/li>\n\n\n\n<li>Fluorescence Microscopy<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Lab Members<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Anam Usmani (PhD)<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Selected publications <\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24253929\/\" class=\"ek-link\">DNA polymerase eta modulates replication fork progression and DNA damage responses in platinum-treated human cells<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23076878\/\" class=\"ek-link\">Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22522008\/\" class=\"ek-link\">COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Most Recent Publications<\/h4>\n\n\n<ul class=\"wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/39457395\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1BkdSGR7C2ZaUW8FAXrtH6JkmBxdd7ACjFyQVGHyEUHnXzH1eZ&#038;fc=20240319101055&#038;ff=20260423102449&#038;v=2.19.0.post6+133c1fe'>Canonical and Non-Canonical Roles of Human DNA Polymerase \u03b7<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/37446864\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1BkdSGR7C2ZaUW8FAXrtH6JkmBxdd7ACjFyQVGHyEUHnXzH1eZ&#038;fc=20240319101055&#038;ff=20260423102449&#038;v=2.19.0.post6+133c1fe'>Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/35198436\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1BkdSGR7C2ZaUW8FAXrtH6JkmBxdd7ACjFyQVGHyEUHnXzH1eZ&#038;fc=20240319101055&#038;ff=20260423102449&#038;v=2.19.0.post6+133c1fe'>DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target<\/a><\/div><\/li><\/ul>\n\n\n<h4 class=\"wp-block-heading\">Quick Links<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><a href=\"https:\/\/www.universityofgalway.ie\/our-research\/people\/biological-chemical-sciences\/michaelcarty\/\" target=\"_blank\" rel=\"noreferrer noopener\">University Profile<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Carty+MP&amp;cauthor_id=35198436\" target=\"_blank\" rel=\"noreferrer noopener\">PubMed<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Carty+MP&amp;cauthor_id=35198436\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Get in Touch!<\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>michael.carty@universityofgalway.ie<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dr Michael Carty Senior Lecturer in Biochemistrymichael.carty@universityofgalway.ie Research interests Research overview Our main research interest is the molecular basis of the response of human cells to DNA damaging agents. This includes investigation of DNA damage response pathways in primary normal&#8230; <a class=\"more-link\" href=\"https:\/\/chromosome.ie\/gae\/groups\/carty\/\">Continue Reading &rarr;<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_eb_attr":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-134","page","type-page","status-publish","hentry","category-groups"],"_links":{"self":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/comments?post=134"}],"version-history":[{"count":36,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/134\/revisions"}],"predecessor-version":[{"id":2187,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/134\/revisions\/2187"}],"up":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/7"}],"wp:attachment":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/media?parent=134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/categories?post=134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/tags?post=134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}