{"id":136,"date":"2023-10-16T08:47:36","date_gmt":"2023-10-16T07:47:36","guid":{"rendered":"https:\/\/ccb.flaus.net\/ccb2\/?page_id=136"},"modified":"2024-05-24T13:20:57","modified_gmt":"2024-05-24T12:20:57","slug":"lahue","status":"publish","type":"page","link":"https:\/\/chromosome.ie\/gae\/groups\/lahue\/","title":{"rendered":"Bob Lahue"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/boblahue-square.jpg\" alt=\"\" class=\"wp-image-1285\" style=\"aspect-ratio:1;width:150px\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/boblahue-square.jpg 400w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/boblahue-square-300x300.jpg 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/boblahue-square-150x150.jpg 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n<p><strong>Prof Bob Lahue<\/strong><\/p>\n\n\n\n<p>Professor in Biochemistry<br>bob.lahue@universityofgalway.ie<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u00c1bhair Sp\u00e9ise<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>DNA mutagenesis<\/li>\n\n\n\n<li>DNA Repair<\/li>\n\n\n\n<li>Trinucleotide Repeat Instability<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Achoimre Taighde<\/h4>\n\n\n\n<p class=\"has-text-align-justify\">Our chromosomes constantly undergo the opposing forces of DNA mutagenesis and DNA repair.  Mutagenesis is incredibly frequent at trinucleotide repeats in families with certain hereditary neurological diseases. These site-specific expansions, or gains of triplet repeats, occur in cells that appear otherwise normal.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">These features suggest that the usual rules governing mutagenesis and repair no longer apply, and that protein activities are altered when acting at triplet repeats.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">We use genetics, biochemistry and cell biology to study triplet repeat expansions in cultured cells of the human central nervous system. The goal of this work is to uncover the molecular mechanisms of how triplet repeats expand, and what protein factors are important in favoring or inhibiting the expansion process.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">To date, the mismatch repair protein MutS\u00df and the histone deacetylases HDAC3 and HDAC5 were identified as key factors that favor expansions. Their activities are counteracted by the DNA helicase RTEL1, which inhibits expansions. The activities of these proteins are currently under active investigation.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Eochairfhocail<\/h4>\n\n\n\n<p>DNA Damage, DNA Repair, Trinucleotide Repeat Expansion, Mismatch Repair.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Baill an Ghr\u00fapa<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dr Karolina Salciute<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in Roghnaithe <\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24561255\/\" class=\"ek-link\">RTEL1 inhibits trinucleotide repeat expansions and fragility<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23337586\/\" class=\"ek-link\">Trinucleotide repeat expansions catalyzed by human cell-free extracts<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22363205\/\" class=\"ek-link\">Histone deacetylase complexes promote trinucleotide repeat expansions<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22941650\/\" class=\"ek-link\">MutSbeta and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in is D\u00e9ana\u00ed<\/h4>\n\n\n<ul class=\"wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40010080\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1reoklHRwDJzycoJg5hU3EIgUbzZs8SA1L-e9YJcRxm-NfPc-Z&#038;fc=20231019070204&#038;ff=20260423052201&#038;v=2.19.0.post6+133c1fe'>Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/34525375\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1reoklHRwDJzycoJg5hU3EIgUbzZs8SA1L-e9YJcRxm-NfPc-Z&#038;fc=20231019070204&#038;ff=20260423052201&#038;v=2.19.0.post6+133c1fe'>SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/33224521\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1reoklHRwDJzycoJg5hU3EIgUbzZs8SA1L-e9YJcRxm-NfPc-Z&#038;fc=20231019070204&#038;ff=20260423052201&#038;v=2.19.0.post6+133c1fe'>New developments in Huntington&#039;s disease and other triplet repeat diseases: DNA repair turns to the dark side<\/a><\/div><\/li><\/ul>\n\n\n<h4 class=\"wp-block-heading\">Nascanna \u00c1isi\u00fala<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><a href=\"https:\/\/www.universityofgalway.ie\/our-research\/people\/biological-chemical-sciences\/boblahue\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Pr\u00f3f\u00edl Ollscoile<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lahue+RS&amp;cauthor_id=34525375\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">PubMed<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/scholar.google.com\/citations?user=rppV7JcAAAAJ&amp;hl=en\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Google Scholar<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">T\u00e9igh i dTeagmh\u00e1il!<\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>bob.lahue@universityofgalway.ie<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Prof Bob Lahue Professor in Biochemistrybob.lahue@universityofgalway.ie Research interests Research overview Our chromosomes constantly undergo the opposing forces of DNA mutagenesis and DNA repair. Mutagenesis is incredibly frequent at trinucleotide repeats in families with certain hereditary neurological diseases. These site-specific expansions,&#8230; <a class=\"more-link\" href=\"https:\/\/chromosome.ie\/gae\/groups\/lahue\/\">Continue Reading &rarr;<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_eb_attr":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-136","page","type-page","status-publish","hentry","category-groups"],"_links":{"self":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/comments?post=136"}],"version-history":[{"count":21,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/136\/revisions"}],"predecessor-version":[{"id":2113,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/136\/revisions\/2113"}],"up":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/7"}],"wp:attachment":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/media?parent=136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/categories?post=136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/tags?post=136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}