{"id":144,"date":"2023-10-16T23:42:30","date_gmt":"2023-10-16T22:42:30","guid":{"rendered":"https:\/\/ccb.flaus.net\/ccb2\/?page_id=144"},"modified":"2025-10-28T15:13:14","modified_gmt":"2025-10-28T15:13:14","slug":"morrison","status":"publish","type":"page","link":"https:\/\/chromosome.ie\/gae\/groups\/morrison\/","title":{"rendered":"Ciaran Morrison"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1666\" height=\"1666\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison.jpg\" alt=\"\" class=\"wp-image-315\" style=\"width:150px\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison.jpg 1666w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-300x300.jpg 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-1024x1024.jpg 1024w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-150x150.jpg 150w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-768x768.jpg 768w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-1536x1536.jpg 1536w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-600x600.jpg 600w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/ciaranmorrison-945x945.jpg 945w\" sizes=\"auto, (max-width: 1666px) 100vw, 1666px\" \/><\/figure>\n<\/div>\n\n\n<p><strong>Prof Ciaran Morrison<\/strong><br>Professor in Biochemistry<br>SFI Award<br>ciaran.morrison@universityofgalway.ie<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Postanna ar F\u00e1il<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PhD (Contact Me)<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u00c1bhair Sp\u00e9ise<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Strucht\u00far an cheintreas\u00f3im <\/li>\n\n\n\n<li>Rial\u00fa ar an l\u00edon ceintreas\u00f3im at\u00e1 i gcealla ailseach<\/li>\n\n\n\n<li>Freagairt na gceintreas\u00f3m ar dam\u00e1iste DNA<\/li>\n\n\n\n<li>Ceintr\u00edn\u00ed agus pr\u00edomhfhabr\u00e1in<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Achoimre Taighde<\/h4>\n\n\n\n<p class=\"has-text-align-justify\">Our research focuses on centrosomes, remarkable structures that organise microtubules in animal somatic cells.&nbsp; They control bipolar spindle formation, regulate cell motility and polarity and also act as the base of cilia.&nbsp; Centrosome abnormalities and amplification are common characteristics of tumour cells. Aneuploidy and chromosomal instability are highly correlated with the appearance of multiple centrosomes. &nbsp;Supernumerary centrosomes can cause mitotic abnormalities, such as the formation of multipolar spindles, potentially giving rise to abnormal chromosome segregation.<strong>&nbsp; <\/strong>Thus, centrosome amplification needs to be tightly regulated during the normal cell cycle.<\/p>\n\n\n\n<figure class=\"wp-block-gallery aligncenter has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"523\" height=\"260\" data-id=\"321\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-Centrioles.jpg\" alt=\"\" class=\"wp-image-321\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-Centrioles.jpg 523w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-Centrioles-300x149.jpg 300w\" sizes=\"auto, (max-width: 523px) 100vw, 523px\" \/><\/figure>\n<\/figure>\n\n\n\n<p class=\"has-text-align-center has-light-gray-color has-text-color has-link-color wp-elements-ba1d84c19a41ff84812d46b82c613dcc\" style=\"font-size:14px;font-style:normal;font-weight:600\">Electron (L) and expansion (R) micrographs of mother and daughter centrioles.  The centriolar microtubules are made of tubulin, shown in magenta.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">Our group explores how centrosomes are assembled under normal and pathological circumstances.&nbsp; Previous work from our group has demonstrated that DNA damage leads to centrosome amplification. &nbsp;One goal of our work is to understand how DNA damage is signalled to the centrosome duplication apparatus and to define the impact this has on proliferating cells. <strong>&nbsp;<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"919\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar-1024x919.jpg\" alt=\"\" class=\"wp-image-322\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar-1024x919.jpg 1024w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar-300x269.jpg 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar-768x690.jpg 768w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar-600x539.jpg 600w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar-945x848.jpg 945w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/CM-multipolar.jpg 1390w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">A multipolar mitotic cell showing the problems caused by multiple centrosomes.&nbsp; Microtubules are in red, chromosomes in blue and the checkpoint protein BubR1 in green.<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-justify\">We also explore how specific components of the centrosome contribute to DNA repair and cell cycle checkpoint activities. &nbsp;Several key proteins of the centriole and the pericentriolar material are directly involved in control of the cell cycle, before and after DNA damage, and we want to establish how they carry out their different functions.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Eochairfhocail<\/h4>\n\n\n\n<p class=\"has-text-align-justify\">Deisi\u00fa de briseadh d\u00e9ribe DNA, timthriall , seasmhacht g\u00e9an\u00f3ma\u00edoch, an freagairt ar dham\u00e1iste DNA, aos\u00fachas ceallach, ceintreas\u00f3m, ceintr\u00edn, fabhr\u00e1in, comhartha\u00edocht cheallach, c\u00falgh\u00e9ineola\u00edocht, micreasc\u00f3ipeacht forbartha.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Cro\u00edtheichn\u00edochat\u00ed Taighde<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Micreasc\u00f3ipeacht<\/li>\n\n\n\n<li>Pr\u00f3it\u00e9ama\u00edocht<\/li>\n\n\n\n<li>Saothr\u00e1n ceall<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Baill an Ghr\u00fapa<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dr. Santiago Camblor-Peruja (PD)<\/li>\n\n\n\n<li>Anushka Sharma (PhD)<\/li>\n\n\n\n<li>Ruth Kearney (PhD)<\/li>\n\n\n\n<li>Sarah O&#8217;Neill (PhD)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in Roghnaithe<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31492759\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29440264\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Centrobin controls primary ciliogenesis in vertebrates<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25753040\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Centrin2 regulates CP110 removal in primary cilium formation<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in is D\u00e9ana\u00ed<\/h4>\n\n\n<ul class=\"wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/41168084\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1fedKcOVZacDs7lQaz98JrrSZhT_Mt0IWCxQ1Q7CjwuqE1VEV3&#038;fc=20231019070936&#038;ff=20260415231530&#038;v=2.19.0.post6+133c1fe'>Lysine demethylase 4A: from chromatin to centrosomes<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40253509\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1fedKcOVZacDs7lQaz98JrrSZhT_Mt0IWCxQ1Q7CjwuqE1VEV3&#038;fc=20231019070936&#038;ff=20260415231530&#038;v=2.19.0.post6+133c1fe'>Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/39472588\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1fedKcOVZacDs7lQaz98JrrSZhT_Mt0IWCxQ1Q7CjwuqE1VEV3&#038;fc=20231019070936&#038;ff=20260415231530&#038;v=2.19.0.post6+133c1fe'>Author Correction: Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner<\/a><\/div><\/li><\/ul>\n\n\n<h4 class=\"wp-block-heading\">Nascanna \u00c1isi\u00fala<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><a href=\"https:\/\/www.universityofgalway.ie\/our-research\/people\/biological-chemical-sciences\/ciaranmorrison\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Pr\u00f3f\u00edl Ollscoile<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MOrrison+cg+OR+%28morrison+c+AND+%28takeda+s+OR+earnshaw+wc+OR+wang+zq+OR+wagner+E+or+Gannon+F%29%29&amp;sort=date&amp;size=100\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">PubMed<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/scholar.google.com\/citations?user=33SrAgMAAAAJ&amp;hl=en\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">Google Scholar<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">T\u00e9igh i dTeagmh\u00e1il!<\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>ciaran.morrison@universityofgalway.ie<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Prof Ciaran MorrisonProfessor in BiochemistrySFI Awardciaran.morrison@universityofgalway.ie Open Positions Research interests Research overview Our research focuses on centrosomes, remarkable structures that organise microtubules in animal somatic cells.&nbsp; They control bipolar spindle formation, regulate cell motility and polarity and also act as&#8230; <a class=\"more-link\" href=\"https:\/\/chromosome.ie\/gae\/groups\/morrison\/\">Continue Reading &rarr;<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_eb_attr":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-144","page","type-page","status-publish","hentry","category-groups"],"_links":{"self":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/comments?post=144"}],"version-history":[{"count":54,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/144\/revisions"}],"predecessor-version":[{"id":2072,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/144\/revisions\/2072"}],"up":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/7"}],"wp:attachment":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/media?parent=144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/categories?post=144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/tags?post=144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}