{"id":39,"date":"2023-03-16T15:05:42","date_gmt":"2023-03-16T15:05:42","guid":{"rendered":"https:\/\/ccb.flaus.net\/ccb2\/?page_id=39"},"modified":"2026-04-10T22:43:59","modified_gmt":"2026-04-10T21:43:59","slug":"dunleavy","status":"publish","type":"page","link":"https:\/\/chromosome.ie\/gae\/groups\/dunleavy\/","title":{"rendered":"Elaine Dunleavy"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"494\" height=\"494\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/elaine-e1710802025827-edited-1.jpg\" alt=\"\" class=\"wp-image-1274\" style=\"width:150px\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/elaine-e1710802025827-edited-1.jpg 494w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/elaine-e1710802025827-edited-1-300x300.jpg 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/elaine-e1710802025827-edited-1-150x150.jpg 150w\" sizes=\"auto, (max-width: 494px) 100vw, 494px\" \/><\/figure>\n<\/div>\n\n\n<p><strong>Dr Elaine Dunleavy<\/strong><br>Senior Lecturer in Biochemistry<br>Dep. Programme Director BSc Genetics &amp; Genomics<br>SFI President of Ireland Young Researcher Award<br>elaine.dunleavy@universityofgalway.ie<\/p>\n\n\n\n<hr class=\"wp-block-separator alignwide has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u00c1bhair Sp\u00e9ise<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sonr\u00fa agus feidhmn na ceintrim\u00edre sa gheirml\u00edne&nbsp;<\/li>\n\n\n\n<li>Bitheola\u00edocht ar cheintrim\u00edr\u00ed speirme&nbsp;<\/li>\n\n\n\n<li>Scaradh na gcr\u00f3mas\u00f3m le linn m\u00e9\u00f3ise agus forbartha tosaigh&nbsp;<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Achoimre Taighde<\/h4>\n\n\n\n<p class=\"has-text-align-justify\">We aim to understand germ cell development in the reproductive tissues, the testis and ovary. Germ cells undergo specialised cell divisions, such as meiosis, to ultimately give rise to gametes (eggs and sperm). Defects in egg and sperm development lead to reduced fertility or sterility. Understanding germ cell division and development is critical, as this information can impact on the diagnosis and treatment of human or animal infertility.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"866\" height=\"862\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/ed2Picture-1.jpg\" alt=\"\" class=\"wp-image-127\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/ed2Picture-1.jpg 866w, https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/ed2Picture-1-300x300.jpg 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/ed2Picture-1-150x150.jpg 150w, https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/ed2Picture-1-768x764.jpg 768w, https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/ed2Picture-1-600x597.jpg 600w\" sizes=\"auto, (max-width: 866px) 100vw, 866px\" \/><figcaption class=\"wp-element-caption\">A field of fruit fly spermatocytes in which an ATP synthase subunit is depleted leading to defects in DNA organization, imaged using wide field microscopy (DNA is shown in green).<\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"202\" height=\"202\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/edPicture-1.png\" alt=\"\" class=\"wp-image-128\" style=\"width:398px;height:auto\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/edPicture-1.png 202w, https:\/\/chromosome.ie\/wp-content\/uploads\/2023\/10\/edPicture-1-150x150.png 150w\" sizes=\"auto, (max-width: 202px) 100vw, 202px\" \/><figcaption class=\"wp-element-caption\">Four fruit fly egg chambers containing germline stem cells, imaged using high resolution confocal microscopy.\n<\/figcaption><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-justify\">Located on each chromosome within the cell nucleus, the centromere plays a key role in cell division. It is the site where the kinetochore assembles to ensure proper chromosome segregation. Rather than DNA sequence, the histone variant CENP-A specifies centromere identity and function in an epigenetic manner.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"488\" height=\"502\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Sperm-cid-image.png\" alt=\"\" class=\"wp-image-234\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Sperm-cid-image.png 488w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/03\/Sperm-cid-image-292x300.png 292w\" sizes=\"auto, (max-width: 488px) 100vw, 488px\" \/><figcaption class=\"wp-element-caption\">Fluorescence image of fully differentiated fly sperma nuclei with centromeres marked in green by a GFP-tag and DNA stained red.<\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-justify\">A key question in the laboratory is to understand how CENP-A is targeted to and reproducibly incorporated at centromeres in the germ line. We focus on germline stem cells, on spermatocytes undergoing meiosis and on developing sperm. <\/p>\n\n\n\n<p class=\"has-text-align-justify\">We use the fruit fly <em>Drosophila melanogaster<\/em> and the cow <em>Bos taurus<\/em> as model developmental systems, combing genetics, high-resolution cell biology and biochemical approaches.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Eochairfhocail<\/h4>\n\n\n\n<p>Ceintrim\u00edr, CENP-A, Miot\u00f3is, M\u00e9\u00f3is, Gaschealla na Geirml\u00edne, Speirmitigineas, Speirmigineas, Drosophila melanogaster, Bos tarus&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:45%\">\n<h4 class=\"wp-block-heading\">Cro\u00edtheichn\u00edochta\u00ed Taighde<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>L\u00e1imhsi\u00fa F\u00edoch\u00e1in<\/li>\n\n\n\n<li>Imdh\u00edonfhluaraiseacht<\/li>\n\n\n\n<li>Hibridi\u00fa Fluaraiseachta In Situ<\/li>\n\n\n\n<li>Micreasc\u00f3ipeacht<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:55%\">\n<h4 class=\"wp-block-heading\">Baill an Ghr\u00fapa<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dr Dina Malkeyeva (Post-Doc)<\/li>\n\n\n\n<li>Rachel Keegan (PhD)<\/li>\n\n\n\n<li>Ben O&#8217;Gorman (PhD)<\/li>\n\n\n\n<li>Anna N\u00ed Nuall\u00e1in (PhD)<\/li>\n\n\n\n<li>Lauren Kirwan (MSc)<\/li>\n\n\n\n<li>Meg Weever (MSc)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in Roghnaithe<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34014920\/\">CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in <em>Drosophila<\/em> germline stem cells<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32328637\/\">Asymmetric assembly of centromeres epigenetically regulates cell fate<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30006572\/\">ATP synthase F<sub>1<\/sub>&nbsp;subunits recruited to centromeres by CENP-A are required for male meiosis<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in is D\u00e9ana\u00ed<\/h4>\n\n\n<ul class=\"wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/41346187\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1J__86CjOXswvosDxZyOwv1u-4aZsAKdMlAF1U1dVG88KL3AF2&#038;fc=20231018094108&#038;ff=20260423022634&#038;v=2.19.0.post6+133c1fe'>Cell cycle timing and centromere positioning in Bos taurus zygotes derived from in vitro fertilization<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40958016\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1J__86CjOXswvosDxZyOwv1u-4aZsAKdMlAF1U1dVG88KL3AF2&#038;fc=20231018094108&#038;ff=20260423022634&#038;v=2.19.0.post6+133c1fe'>CENP-A is diluted during bovine spermatogenesis and is maintained at internally positioned centromere clusters in mature bull sperm<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/pubmed.ncbi.nlm.nih.gov\/40281341\/?utm_source=WordPress&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1J__86CjOXswvosDxZyOwv1u-4aZsAKdMlAF1U1dVG88KL3AF2&#038;fc=20231018094108&#038;ff=20260423022634&#038;v=2.19.0.post6+133c1fe'>Marking dad&#039;s centromeres: maintaining CENP-A in sperm<\/a><\/div><\/li><\/ul>\n\n\n<h4 class=\"wp-block-heading\">Nascanna \u00c1isi\u00fala<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><a href=\"https:\/\/www.universityofgalway.ie\/our-research\/people\/biological-chemical-sciences\/elainedunleavy\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pr\u00f3f\u00edl Ollscoile<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dunleavy+EM&amp;cauthor_id=23300382\" target=\"_blank\" rel=\"noreferrer noopener\">PubMed<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/scholar.google.com\/citations?user=aJnCtXwAAAAJ&amp;hl=en\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">T\u00e9igh i dTeagmh\u00e1il!<\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>elaine.dunleavy@universityofgalway.ie<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Dr Elaine DunleavySenior Lecturer in BiochemistryDep. Programme Director BSc Genetics &amp; GenomicsSFI President of Ireland Young Researcher Awardelaine.dunleavy@universityofgalway.ie Research Interests Research Overview We aim to understand germ cell development in the reproductive tissues, the testis and ovary. Germ cells undergo&#8230; <a class=\"more-link\" href=\"https:\/\/chromosome.ie\/gae\/groups\/dunleavy\/\">Continue Reading &rarr;<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_eb_attr":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-39","page","type-page","status-publish","hentry","category-groups"],"_links":{"self":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":145,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":2188,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/39\/revisions\/2188"}],"up":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/7"}],"wp:attachment":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/media?parent=39"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/categories?post=39"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/tags?post=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}