{"id":63,"date":"2023-08-08T00:15:15","date_gmt":"2023-08-07T23:15:15","guid":{"rendered":"https:\/\/ccb.flaus.net\/ccb2\/?page_id=63"},"modified":"2026-04-22T10:56:03","modified_gmt":"2026-04-22T09:56:03","slug":"frank","status":"publish","type":"page","link":"https:\/\/chromosome.ie\/gae\/groups\/frank\/","title":{"rendered":"Uri Frank"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"346\" height=\"346\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/uri-frank-background-removebg-preview-e1710796132982-edited.png\" alt=\"\" class=\"wp-image-1278\" style=\"width:150px\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/uri-frank-background-removebg-preview-e1710796132982-edited.png 346w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/uri-frank-background-removebg-preview-e1710796132982-edited-300x300.png 300w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/04\/uri-frank-background-removebg-preview-e1710796132982-edited-150x150.png 150w\" sizes=\"auto, (max-width: 346px) 100vw, 346px\" \/><\/figure>\n<\/div>\n\n\n<p>Prof Uri Frank<br>Professor in Biochemistry<br>Wellcome &amp; SFI Investigator and EMBO Member<br>uri.frank@universityofgalway.ie<br><a href=\"https:\/\/www.urifranklab.org\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\">Frank Lab Website<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">\u00c1bhair Sp\u00e9ise<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bitheola\u00edocht Forbartha<\/li>\n\n\n\n<li>Gaschealla &amp; Cillchumas<\/li>\n\n\n\n<li>Athghini\u00faint F\u00edoch\u00e1in<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Achoimre Taighde<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-text-align-justify\">We study how cells make decisions during development and regeneration using molecular genetics, genomics, imaging, and functional studies. For our research, we use the cnidarian&nbsp;<em>Hydractinia<\/em>&nbsp;as a model system. This animal has quite unique biological features and can be manipulated with relative ease.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-justify\"><em>Hydractinia<\/em>&nbsp;is a clonal and colonial animal. Embryos develop within three days into a swimming larva called planula. Upon metamorphosis, which takes 24 hours, they transform into the adult form called a polyp. <\/p>\n\n\n\n<p class=\"has-text-align-justify\">Polyps are sessile (we grow them on microscope glass slides). Upon metamorphosis, they start making genetic copies of themselves by asexual budding, forming a colony of genetically identical individuals (i.e. a clone).<\/p>\n\n\n\n<p><em>Hydractinia&nbsp;<\/em>possesses<em>&nbsp;<\/em>adult stem cells, known as i-cells. These cells are thought to contribute to all somatic lineages of the animal and to germ cells. i-cells are a major focus of our work. <\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"763\" height=\"1024\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-species-763x1024.png\" alt=\"\" class=\"wp-image-1549\" style=\"width:268px;height:auto\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-species-763x1024.png 763w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-species-224x300.png 224w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-species-600x805.png 600w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-species.png 769w\" sizes=\"auto, (max-width: 763px) 100vw, 763px\" \/><\/figure>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"342\" height=\"540\" src=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-Polyp.png\" alt=\"\" class=\"wp-image-1546\" srcset=\"https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-Polyp.png 342w, https:\/\/chromosome.ie\/wp-content\/uploads\/2024\/05\/Hydractinia-Polyp-190x300.png 190w\" sizes=\"auto, (max-width: 342px) 100vw, 342px\" \/><figcaption class=\"wp-element-caption\">The neural network of an adult <em>Hydractinia<\/em> polyp. RFamide stained in green.<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-justify\">We study how they make different cell types like neurons and gametes. i-cells can migrate in the tissues and are recruited to major injury sites where they contribute to regeneration.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Eochairfhocail<\/h4>\n\n\n\n<p>Gaschealla, Nideog, Comhartha\u00edocht, Difre\u00e1il, D\u00eddhifre\u00e1il, PLURIPOTENCY, iCealla, Hydractinia, L\u00e9arsc\u00e1il G\u00e9ine, Tosca Thras-scr\u00edofa, Athghini\u00faint.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Baill an Ghr\u00fapa<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dr Yasmine Lund-Ricard (Post-Doc)<\/li>\n\n\n\n<li>Dr Matthew Travert (Post-Doc)<\/li>\n\n\n\n<li>Dr Marta Mammone (Post-Doc)<\/li>\n\n\n\n<li>Rowan Mac Gabhann (PhD)<\/li>\n\n\n\n<li>Paris Weavers (PhD)<\/li>\n\n\n\n<li>Paula Hillenbrand (PhD)<\/li>\n\n\n\n<li>Mary Liza Gannon (PhD)<\/li>\n\n\n\n<li>Cian Lawless (RA &amp; MSc)<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Cro\u00edtheichn\u00edochta\u00ed Taighde<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>L\u00e1imhsi\u00fa F\u00edoch\u00e1in<\/li>\n\n\n\n<li>Micreasc\u00f3pacht Fluaraiseach<\/li>\n\n\n\n<li>Bithfh\u00e1isn\u00e9is\u00edocht<\/li>\n\n\n\n<li>Genome Editing &amp; Transgenesis<\/li>\n\n\n\n<li>In-situ Hybridisation<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Foilseach\u00e1in Roghnaithe <\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Curantz C, Krasovec G, Horkan HR, Ryan LM, Varley A, Frank U (2025). An unexpected mode of whole-body regeneration from reaggregated cell suspension in <em>Hydractinia<\/em> (Cnidaria, Hydrozoa). <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.01.06.631080v1\" target=\"_blank\" rel=\"noreferrer noopener\"><em>bioRxiv<\/em><\/a>.<\/li>\n\n\n\n<li>Salamanca-D\u00edaz, DA, Horkan HR, Garc\u00eda-Castro H, Emili E, Salinas-Saavedra M, Rossi ME, \u00c1lvarez-Presas M, Mac Gabhann R, Febrimarsa, P\u00e9rez-Posada A, Kenny NJ, Paps J, Frank, U, Solana J. (2025). The <em>Hydractinia<\/em> cell atlas reveals cellular and molecular principles of cnidarian coloniality. <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-57168-z\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Nature Communications<\/em> 16, 2121<\/a>.<\/li>\n\n\n\n<li>Curantz C, Doody C, Krasovec G, Weavers PK, DuBuc TQ, Frank U (2025). A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian. <a href=\"https:\/\/dx.doi.org\/10.1126\/sciadv.adq8220\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Science Advances<\/em> 11(2):1-<\/a><a href=\"https:\/\/dx.doi.org\/10.1126\/sciadv.adq8220\">9<\/a>.<\/li>\n\n\n\n<li>Admoni Y, Fridrich A, Weavers PK, Aharoni R, Razin T, Salinas-Saavedra M, Rabani M, Frank U, Moran Y. (2025). Target complementarity in cnidarians supports a common origin for animal and plant microRNAs. <a href=\"https:\/\/doi.org\/10.1038\/s44319-024-00350-z\" target=\"_blank\" rel=\"noreferrer noopener\"><em>EMBO Reports<\/em> 26: 836 \u2013 859<\/a>.<\/li>\n\n\n\n<li>Krasovec G, Frank U. (2024). Apoptosis-dependent head development during metamorphosis of the cnidarian <em>Hydractinia symbiolongicarpus<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.ydbio.2024.08.010\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Developmental Biolog<\/em><\/a><a href=\"https:\/\/doi.org\/10.1016\/j.ydbio.2024.08.010\"><em>y<\/em><\/a><a href=\"https:\/\/doi.org\/10.1016\/j.ydbio.2024.08.010\" target=\"_blank\" rel=\"noreferrer noopener\"> 516: 148-154<\/a>.<\/li>\n\n\n\n<li>Schnitzler CE, Chang ES, Waletich J, Quiroga-Artigas G, Wong WY, Nguyen AD, Barreira S, Doonan LB, Gonzalez P, Koren S, Gahan J, Sanders S, Bradshaw B, DuBuc T, Febrimarsa F, de Jong D, Nawrocki E, Larson A, Klasfeld S, Gornik S, Moreland RT, Wolfsberg T, Phillippy AM, Mullikin J, Simakov O, Cartwright P, Nicotra M, Frank U, Baxevanis AD (2024). The genome of the colonial hydroid <em>Hydractinia<\/em> reveals their stem cells utilize a toolkit of evolutionarily shared genes with all animals. <a href=\"https:\/\/doi.org\/10.1101\/gr.278382.123\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Genome Research<\/em> 25;34(3):498-513<\/a>.<\/li>\n\n\n\n<li>Febrimarsa, Gornik SG, Barreira SN, Salinas-Saavedra M, Schnitzler CE, Baxevanis AD, Frank U (2023). Randomly incorporated genomic 6mA delays zygotic transcription initiation in a cnidarian. <a href=\"https:\/\/doi.org\/10.15252\/embj.2022112934\" target=\"_blank\" rel=\"noreferrer noopener\"><em>The EMBO Journal<\/em> 42(15) e112934<\/a>.<\/li>\n\n\n\n<li>Salinas-Saavedra M, Febrimarsa, Krasovec G, Horkan HR, Baxevanis AD, Frank U (2023). Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration. <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112687\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Cell Reports<\/em> 42(7)<\/a>.<\/li>\n\n\n\n<li>Varley A, Horkan HR, McMahon ET, Krasovec G, Frank U (2023). Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth.<a href=\"https:\/\/doi.org\/10.1016\/j.cub.2023.03.039\" target=\"_blank\" rel=\"noreferrer noopener\"><em> Current Biology<\/em> 33 (10):1883\u20131892<\/a>. <a href=\"https:\/\/www.cell.com\/current-biology\/issue?pii=S0960-9822(22)X0011-0#fullCover\" target=\"_blank\" rel=\"noreferrer noopener\">Cover article<\/a>. <a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(23)00518-3\" target=\"_blank\" rel=\"noreferrer noopener\">Dispatch<\/a>.<\/li>\n\n\n\n<li>Kon-Nanjo K, Kon T, Horkan HR, Febrimarsa, Frank U, Simakov O (2023). A chromosome-level genome assembly of <em>Hydractinia<\/em> <em>symbiolongicarpus<\/em> using PacBio HiFi long-read sequencing and Hi-C scaffolding. <a href=\"https:\/\/academic.oup.com\/g3journal\/advance-article\/doi\/10.1093\/g3journal\/jkad107\/7170730?login=false\" target=\"_blank\" rel=\"noreferrer noopener\"><em>G<\/em><\/a><a href=\"https:\/\/doi.org\/10.1093\/g3journal\/jkad107\" target=\"_blank\" rel=\"noreferrer noopener\"><em>3<\/em> 13(8) jkad107<\/a>.<\/li>\n\n\n\n<li>Fridrich A, Salinas-Saavedra M, Kozlovski I, Surm JM, Chrysostomou E, Abhinandan M Tripathi AM, Frank U, Moran Y. (2023). A pan-cnidarian microRNA is an ancient biogenesis regulator of stinging cells. <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.113072\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Cell Reports<\/em> 42(9) 113072<\/a>.<\/li>\n\n\n\n<li>T\u00f6r\u00f6k A, Browne, MJG, Vilar JC, Patwal I, DuBuc TQ, Febrimarsa, Acheson, Frank U, Gornik SG, Flaus A. (2023). Hydrozoan sperm-specific SPKK motif-containing histone H2B variants stabilise chromatin with limited compaction. <a href=\"https:\/\/journals.biologists.com\/dev\/article-pdf\/150\/1\/dev201058\/2428130\/dev201058.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Development<\/em> 150 (1)<\/a>.<\/li>\n\n\n\n<li>Chrysostomou E, Flici H, Gornik SG, Salinas-Saavedra M, Gahan JM, McMahon ET, Thompson K, Hanley S, Kilcoyne M, Schnitzler CE, Gonzalez P, Baxevanis AD, Frank U (2022). A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian. <a href=\"https:\/\/elifesciences.org\/articles\/78793\" target=\"_blank\" rel=\"noreferrer noopener\"><em>eLife<\/em><\/a>.<\/li>\n\n\n\n<li>Chrysostomou E, Febrimarsa, DuBuc T, Frank U (2022). Methods for gene manipulation in <em>Hydractinia. <\/em><a href=\"https:\/\/link.springer.com\/protocol\/10.1007\/978-1-0716-2172-1_22#DOI\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Methods in Molecular Biology<\/em><\/a>.<\/li>\n\n\n\n<li>Frank U, Nicotra ML, Schnitzler CE (2020). The colonial cnidarian <em>Hydractinia<\/em>. <a href=\"https:\/\/link.springer.com\/epdf\/10.1186\/s13227-020-00151-0?author_access_token=_K1smMmZb2K_oVu1FaOK_G_BpE1tBhCbnbw3BuzI2RPLiFROR9M-XZTWmWsXhYREgZHl3aF9dL0D-fgWQV3i7_Lr7SVuaLkSqGd15SmtevZeGRAQ0HMSwxJlqldDIwakDsMLsffM6n-KJ-_Y3s6zXQ%3D%3D\" target=\"_blank\" rel=\"noreferrer noopener\"><em>EvoDevo<\/em> 11:<\/a>.<\/li>\n\n\n\n<li>DuBuc TQ, Schnitzler CE, Chrysostomou E, McMahon ET, Febrimarsa, Gahan JM, Buggie T, Gornik SG, Hanley S, Barreira SN, Gonzalez, P, Baxevanis AD, Frank U (2020). Transcription factor AP2 controls cnidarian germ cell induction.&nbsp;<a href=\"http:\/\/science.sciencemag.org\/cgi\/content\/full\/367\/6479\/757?ijkey=l18IO8qiXgWrI&amp;keytype=ref&amp;siteid=sci\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Science<\/em> 367: 757-762<\/a>.<\/li>\n\n\n\n<li>Funayama N, Frank U (2019). Meeting Report on \u201cAt the Roots of Bilaterian Complexity: Insights from Early Emerging Metazoans,\u201d Tutzing (Germany) September 16-19, 2019.&nbsp;<a href=\"https:\/\/doi.org\/10.1002\/bies.201900236\"><em>Bioessays<\/em>&nbsp;e1900236<\/a>. <\/li>\n\n\n\n<li>Sanders SM, Ma Z, Hughes JM, Riscoe BM, Gibson GA, Watson AM, Flici H, Frank U, Schnitzler CE, Baxevanis AD, Nicotra, ML (2018). CRISPR\/Cas9-mediated gene knockin in the hydroid <em>Hydractinia symbiolongicarpus<\/em>.&nbsp;<a href=\"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-018-5032-z\" target=\"_blank\" rel=\"noreferrer noopener\"><em>BMC Genomics<\/em>&nbsp;19(1):649<\/a>.<\/li>\n\n\n\n<li>Flici H, Frank U (2018). Inhibition of SoxB2 or HDACs suppresses <em>Hydractinia<\/em> head regeneration by affecting blastema formation.&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6067865\/\"><em>Communicative &amp; Integrative Biology<\/em>&nbsp;e1450032<\/a>.<\/li>\n\n\n\n<li>Ballarin L, Rinkevich B, Bartscherer K, Burzynski A, Cambier S, Cammarata M, Domart-Coulon I, Drobne D, Encinas J, Frank U<em>&nbsp;et al<\/em>&nbsp;(2018). Maristem\u2014Stem Cells of Marine\/Aquatic Invertebrates: From Basic Research to Innovative Applications.&nbsp;<a href=\"https:\/\/www.mdpi.com\/2071-1050\/10\/2\/526\"><em>Sustainability<\/em>&nbsp;10(2):526<\/a>.<\/li>\n\n\n\n<li>Gahan JM, Schnitzler CE, DuBuc TQ, Doonan LB, Kanska J, Gornik SG, Barreira S, Thompson K, Schiffer P, Baxevanis AD, Frank U&nbsp;(2017). Functional studies on the role of Notch signaling in&nbsp;<em>Hydractinia<\/em>&nbsp;development.&nbsp;<em>Dev Biol<\/em>&nbsp;428(1):224-231. <a href=\"https:\/\/reader.elsevier.com\/reader\/sd\/pii\/S0012160617301641?token=F045A6CDEF9E5FD016BB3BC20DCABD3C8AB4C98C3287C5C1E16BA28B64759E454580981E0213098306B229EEB0EFB0F3\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li>\n\n\n\n<li>Flici H, Schnitzler CE, Millane RC, Govinden G, Houlihan A, Boomkamp SD, Shen S, Baxevanis AD, Frank U (2017). An evolutionarily conserved SoxB-Hdac2 crosstalk regulates neurogenesis in a cnidarian.&nbsp;<em>Cell Reports<\/em>&nbsp;18:1395-1409. <a href=\"https:\/\/www.cell.com\/action\/showPdf?pii=S2211-1247%2817%2930055-4\" target=\"_blank\" rel=\"noreferrer noopener\">PDF<\/a><\/li>\n\n\n\n<li>Torok A, Schiffer PH, Schnitzler CE, Ford K, Mullikin JC, Baxevanis AD, Bacic A, Frank U, Gornik SG (2016). The cnidarian&nbsp;<em>Hydractinia echinata<\/em>&nbsp;employs canonical and highly adapted histones to pack its DNA.<a href=\"https:\/\/epigeneticsandchromatin.biomedcentral.com\/articles\/10.1186\/s13072-016-0085-1\">&nbsp;<em>Epigenetics Chromatin<\/em>&nbsp;9(1):36.<\/a><\/li>\n\n\n\n<li>Gahan JM, Bradshaw B, Flici H, Frank U (2016). The interstitial stem cells in&nbsp;<em>Hydractinia<\/em>&nbsp;and their role in regeneration.&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.gde.2016.06.006\"><em>Curr Opin Genet Dev&nbsp;<\/em>40:65-73<\/a>. <\/li>\n\n\n\n<li>Bradshaw B, Thompson K, Frank U (2015). Distinct mechanisms underlie oral vs aboral regeneration in the cnidarian&nbsp;<em>Hydractinia echinata<\/em>.&nbsp;<em>eLife&nbsp;<\/em>4:e05506. <a href=\"https:\/\/elifesciences.org\/articles\/05506\" target=\"_blank\" rel=\"noreferrer noopener\">Full text<\/a><\/li>\n\n\n\n<li>Kraus Y, Flici H, Hensel K, Plickert G, Leitz T, Frank U (2014). The embryonic development of the cnidarian Hydractinia echinata.&nbsp;<a href=\"https:\/\/doi.org\/10.1111\/ede.12100\"><em>Evol Dev&nbsp;<\/em>16(6):323-338<\/a>.<\/li>\n\n\n\n<li>Hensel K, Lotan T, Sanders SM, Cartwright P, Frank U (2014). Lineage-specific evolution of cnidarian Wnt ligands.&nbsp;<a href=\"https:\/\/doi.org\/10.1111\/ede.12089\"><em>Evol Dev<\/em>16(5):259-69<\/a>. <\/li>\n\n\n\n<li>Kanska J, Frank U (2013). New roles for Nanos in neural cell fate determination revealed by studies in a cnidarian.&nbsp;<a href=\"https:\/\/journals.biologists.com\/jcs\/article\/126\/14\/3192\/53791\/New-roles-for-Nanos-in-neural-cell-fate\"><em>J Cell Sci&nbsp;<\/em>126(14):3192-3203<\/a>.<\/li>\n\n\n\n<li>Plickert G, Frank U, Muller WA (2012).&nbsp;<em>Hydractinia<\/em>, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency.&nbsp;<a href=\"https:\/\/doi.org\/10.1387\/ijdb.123502gp\"><em>Int J Dev Biol&nbsp;<\/em>56(6-7-8):519-534<\/a>.<\/li>\n\n\n\n<li>Millane RC, Kanska J, Duffy DJ, Seoighe C, Cunningham S, Plickert G, Frank U (2011). Induced stem cell neoplasia in a cnidarian by ectopic expression of a POU domain transcription factor.&nbsp;<a href=\"https:\/\/journals.biologists.com\/dev\/article\/138\/12\/2429\/44423\/Induced-stem-cell-neoplasia-in-a-cnidarian-by\"><em>Development&nbsp;<\/em>138(12):2429-2439<\/a>.<\/li>\n\n\n\n<li>Mali B, Millane RC, Plickert G, Frohme M, Frank U (2011). A polymorphic, thrombospondin domain-containing lectin is an oocyte marker in&nbsp;<em>Hydractinia<\/em>: implications for germ cell specification and sex determination.&nbsp;<a href=\"https:\/\/ijdb.ehu.eus\/article\/pdf\/103063bm\"><em>Int J Dev Biol&nbsp;<\/em>55:103-108<\/a>.<\/li>\n\n\n\n<li>Duffy DJ, Millane RC, Frank U (2011). A heat shock protein and Wnt signaling crosstalk during axial patterning and stem cell proliferation.&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0012160611013960?via%3Dihub\"><em>Bitheola\u00edocht Forbartha&nbsp;<\/em>362(2):271-281<\/a>.<\/li>\n\n\n\n<li>Duffy DJ, Frank U (2011). Modulation of COUP-TF Expression in a Cnidarian by Ectopic Wnt Signalling and Allorecognition.&nbsp;<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0019443\"><em>PLoS ONE&nbsp;<\/em>6(4):e19443<\/a>.<\/li>\n\n\n\n<li>Soza-Ried J, Hotz-Wagenblatt A, Glatting KH, Del Val C, Fellenberg K, Bode HR, Frank U, Hoheisel JD, Frohme M (2010). The transcriptome of the colonial marine hydroid Hydractinia echinata.&nbsp;<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1742-4658.2009.07474.x\"><em>FEBS J&nbsp;<\/em>277(1):197-209<\/a>.<\/li>\n\n\n\n<li>K\u00fcnzel T, Heiermann R, Frank U, M\u00fcller WA, Tilmann W, Bause M, Nonn A, Helling M, Schwarz RS, Plickert G (2010). Migration and differentiation potential of stem cells in the cnidarian&nbsp;<em>Hydractinia<\/em>&nbsp;analysed in GFP-transgenic animals and chimeras.<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0012160610010158?via%3Dihub\">&nbsp;<em>Dev Biol&nbsp;<\/em>348:120-129<\/a>.<\/li>\n\n\n\n<li>Duffy DJ, Plickert G, K\u00fcnzel T, Tilmann W, Frank U (2010). Wnt signaling promotes oral but suppresses aboral structures in&nbsp;<em>Hydractinia<\/em>&nbsp;metamorphosis and regeneration.&nbsp;<a href=\"https:\/\/journals.biologists.com\/dev\/article\/137\/18\/3057\/43933\/Wnt-signaling-promotes-oral-but-suppresses-aboral\"><em>Development&nbsp;<\/em>137(18):3057-3066<\/a>.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Nascanna \u00c1isi\u00fala<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><a href=\"https:\/\/www.universityofgalway.ie\/remedi\/who-we-are\/principalinvestigators\/profurifrank\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pr\u00f3f\u00edl Ollscoile<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Frank+U&amp;cauthor_id=27379898\" target=\"_blank\" rel=\"noreferrer noopener\">PubMed<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-right\"><a href=\"https:\/\/scholar.google.com\/citations?user=jn8NC1kAAAAJ&amp;hl=en\" target=\"_blank\" rel=\"noreferrer noopener\">Google Scholar<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">T\u00e9igh i dTeagmh\u00e1il!<\/h4>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>uri.frank@universityofgalway.ie<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Prof Uri FrankProfessor in BiochemistryWellcome &amp; SFI Investigator and EMBO Memberuri.frank@universityofgalway.ieFrank Lab Website Research interests Research overview We study how cells make decisions during development and regeneration using molecular genetics, genomics, imaging, and functional studies. For our research, we use&#8230; <a class=\"more-link\" href=\"https:\/\/chromosome.ie\/gae\/groups\/frank\/\">Continue Reading &rarr;<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_eb_attr":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-63","page","type-page","status-publish","hentry","category-groups"],"_links":{"self":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/63","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/comments?post=63"}],"version-history":[{"count":36,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/63\/revisions"}],"predecessor-version":[{"id":2194,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/63\/revisions\/2194"}],"up":[{"embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/pages\/7"}],"wp:attachment":[{"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/media?parent=63"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/categories?post=63"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chromosome.ie\/gae\/wp-json\/wp\/v2\/tags?post=63"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}