Michael Carty

Dr Michael Carty

Ard-Léachtóir sa Bhithcheimic

Ábhair Spéise

An fhreagairt daonna ar dhámáiste DNA de bharr radaíocht UV nó dámáiste cisplatin
Polaiméaráis DNA eta le linn sinteise na trasloit
Oibreáin frithailse nua

Achoimre ar Thaighde

Our main research interest is the molecular basis of the response of human cells to DNA damaging agents. This includes investigation of DNA damage response pathways in primary normal human melanocytes exposed to long-wavelength UVA light, as well as mechanistic studies of the response to human cells to DNA damage-induced replication arrest.

We focus on the role of the human POLH gene product DNA polymerase eta in translesion synthesis, and on the activation of downstream damage signalling pathways, in particular PIK kinase-mediated phosphorylation of replication protein A (RPA).

The response of human mesenchymal stem cells to platinum-based chemotherapeutic agents or ionising radiation has been investigated in collaboration with the Regenerative Medicine Institute at NUI, Galway.

Mechanistic studies of the response to human cells to DNA damage-induced replication arrest focus on the role of the human POLH gene product DNA polymerase eta in translesion synthesis, and on the activation of downstream damage signalling pathways, in particular PIK kinase-mediated phosphorylation of replication protein A (RPA).

We have an ongoing collaboration with Dr. F. Aldabbagh, School of Chemistry, NUI, Galway to characterise the effects of novel derivatives of the anti-cancer drug mitomycin C on normal and cancer cell lines.

Eochairfhocail

Ailse, rádaíocht UV, An Fhreagairt ar Dhámaiste DNA, cisplatin, sintéis na trasloit, Pol eta, POLH, cionáis PIK, géinte comhtháite, ceimiteiripe, teiripic