Noel Lowndes
Prof Noel Lowndes
Established Professor of Biochemistry
Director of the CCB
SFI Future Frontiers & EMBO Member
noel.lowndes@universityofgalway.ie
Ábhair Spéise
- An ról atá ag cionáise mar PIK (PIKKs) sa sheasmhacht géanómaíoch
- Deisiú de briseadh déribe DNA atá ag brath ar cinéisiní & 53BP1
- Na róil ag próitéiní sincmhéire sa chomharthaíocht & deisiú briseadh dsDNA
- Rialú ar scoitheadh cíticinéise de bharr ATR
Achoimre ar Thaighde
Pathways required to maintain genome stability are potently tumour suppressive, while genome instability is a hallmark of cancer. Our research aims to elucidate novel mechanisms controlling genome stability. While our focus is on fundamental cell biology, future translational studies may ultimately have clinical impact. We utilise genome editing, proteomics, in vitro biochemistry and microscopy to identify and dissect novel genome stability factors. Our principle models are established transformed and immortalised human cell lines (e.g. HCT293, HeLa, U2OS, hTERT-RPE1 cells). In addition, we use primary animal fibroblasts (e.g. mouse, bat).
Eochairfhocail
ATM, ATR, scoitheadh, seicphointí, deisiú DNA, cinéisiní, 53BP1
Íomhánna Roghnaithe
Croítheichníochtaí Taighde
- Modhnú Géanóim
- Bithcheimic Prótéiné & Próitéamaíocht
- Damáiste DNA & Measúnachtaí ar Thimthriall Cille
- Micreascópacht Fluaraiseach & Forbartha
Baill an Ghrúpa
- Dr Ilze Skujina (Post-Doc)
- Dr Floriane Pereira (Post-Doc)
- Emer Brennan (PhD)
- Eoin Gillespie (PhD)
- Sabrinna Crowley (PhD)
- Peng Wu (PhD)
- Anna-Marie Meaney (RA & MSc)
Meantóir / Óstach do...
Dr Janna Luessing
Senior Researcher
SFI-IRC Pathway Programme
janna.luessing@universityofgalway.ie
.
Foilseacháin Roghnaithe
- The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
- A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
- ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset
- Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines
- Budding yeast Rad9 is an ATP-dependent Rad53 activating machine
Foilseacháin is Déanaí
Nascanna Áisiúil
Téigh i dTeagmháil!
noel.lowndes@universityofgalway.ie