Prof Noel Lowndes
Established Professor of Biochemistry
Director of the CCB
SFI Future Frontiers & EMBO Member
noel.lowndes@universityofgalway.ie


Ábhair Spéise

  • An ról atá ag cionáise mar PIK (PIKKs) sa sheasmhacht géanómaíoch
  • Deisiú de briseadh déribe DNA atá ag brath ar cinéisiní & 53BP1
  • Na róil ag próitéiní sincmhéire sa chomharthaíocht & deisiú briseadh dsDNA
  • Rialú ar scoitheadh cíticinéise de bharr ATR

Achoimre ar Thaighde

Pathways required to maintain genome stability are potently tumour suppressive, while genome instability is a hallmark of cancer. Our research aims to elucidate novel mechanisms controlling genome stability. While our focus is on fundamental cell biology, future translational studies may ultimately have clinical impact. We utilise genome editing, proteomics, in vitro biochemistry and microscopy to identify and dissect novel genome stability factors. Our principle models are established transformed and immortalised human cell lines (e.g. HCT293, HeLa, U2OS, hTERT-RPE1 cells). In addition, we use primary animal fibroblasts (e.g. mouse, bat).

Eochairfhocail

ATM, ATR, scoitheadh, seicphointí, deisiú DNA, cinéisiní, 53BP1

Íomhánna Roghnaithe

Croítheichníochtaí Taighde

  • Modhnú Géanóim
  • Bithcheimic Prótéiné & Próitéamaíocht
  • Damáiste DNA & Measúnachtaí ar Thimthriall Cille
  • Micreascópacht Fluaraiseach & Forbartha

Baill an Ghrúpa

  • Dr Ilze Skujina (Post-Doc)
  • Dr Floriane Pereira (Post-Doc)
  • Emer Brennan (PhD)
  • Eoin Gillespie (PhD)
  • Sabrinna Crowley (PhD)
  • Peng Wu (PhD)
  • Anna-Marie Meaney (RA & MSc)

Meantóir / Óstach do...

Dr Janna Luessing
Senior Researcher
SFI-IRC Pathway Programme
janna.luessing@universityofgalway.ie

Foilseacháin Roghnaithe

Foilseacháin is Déanaí

Nascanna Áisiúil

Téigh i dTeagmháil!

noel.lowndes@universityofgalway.ie