Prof Noel Lowndes
Established Professor of Biochemistry
Director of the CCB
SFI Future Frontiers & EMBO Member

Ábhair Spéise

  • Role of phosphatidylinositol 3-kinase like kinases (PIKKs) in genome stability
  • Kinesins & 53BP1-dependent DNA double strand break repair
  • Zinc finger protein roles in DNA double strand break signalling & repair
  • Regulation of cytokinetic abscission by ATR

Achoimre ar Thaighde

Pathways required to maintain genome stability are potently tumour suppressive, while genome instability is a hallmark of cancer. Our research aims to elucidate novel mechanisms controlling genome stability. While our focus is on fundamental cell biology, future translational studies may ultimately have clinical impact. We utilise genome editing, proteomics, in vitro biochemistry and microscopy to identify and dissect novel genome stability factors. Our principle models are established transformed and immortalised human cell lines (e.g. HCT293, HeLa, U2OS, hTERT-RPE1 cells). In addition, we use primary animal fibroblasts (e.g. mouse, bat).


ATM, ATR, abscission, checkpoints, DNA repair, kinesins, 53BP1

Íomhánna Roghnaithe

Croítheichníochtaí Taighde

  • Genome editing
  • Protein biochemistry & proteomics
  • DNA damage & cell cycle assays
  • Fluorescence & expansion microscopy

Baill an Ghrúpa

  • Dr Ilze Skujina (Post-Doc)
  • Shaylee Kieffer (PhD)
  • Emer Brennan (PhD)
  • Eoin Gillespie (PhD)
  • Sabrinna Crowley (PhD)
  • Peng Wu (PhD)

Meantóir / Óstach do...

Dr Janna Luessing
Senior Researcher
SFI-IRC Pathway Programme

Foilseacháin Roghnaithe

Foilseacháin is Déanaí

Nascanna Áisiúil

Téigh i dTeagmháil!