Corrado Santocanale

Prof Corrado Santocanale
Professor of Molecular Medicine
SFI Future Frontiers
corrado.santocanale@universityofgalway.ie
Santocanale Lab Website
Vacant Positions
- 3 Year funded post-doc position. See description.
Ábhair Spéise
- Róil ag cionáis 7 an timthrialla cille (CDC7)
- Rialú ar thosú agus forchéimniú macasamlaithe DNA daonna
- Freagairtí ceallacha ar réamhdhrugaí dírithe ar mhacasamlú DNA.
Achoimre ar Thaighde
The process of DNA replication is the biggest threat for genome stability in proliferating cells. Cancer cells in particular are subjected to replication stress after activation of proto-oncogenes into their oncogenic forms or due to deficiency in specific factors required for genome duplication.
Thus, aberrant DNA replication contributes to initiating and maintaining the cancerous state, while drugs targeting DNA synthesis have potent antitumor activity and are key component of current and novel chemo-therapeutic regimens.

We apply modern techniques of Molecular and Cellular Biology as well Chemical Biology and Genomics approaches to reveal how cells duplicate their DNA and to understand cellular responses when this process is perturbed by either intrinsic or extrinsic factors.

Eochairfhocail
Macasamhlú DNA, ailse, CDC7, DBF4, ATR, MCMs, CRISPR, coscairí cionáise, an timthriall cille, bithfháisnéisíocht.
Croítheichníochtaí Taighde
- Modhnú Géanóim
- Measúnachtaí ar mhacasamhlú DNA ar leibhéal móilín amháin
- Bitheolaíocht móilíneach, ceallach agus ceimiceach
Baill an Ghrúpa
- Dr Michael Rainey (Post-Doc)
- Daniel Shamavu (PhD)
- Stefanus Bernard (PhD)
- Liadhan Farrell (PhD)
Foilseacháin Roghnaithe
- ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
- CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage
- DNA mediated chromatin pull-down for the study of chromatin replication
- A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
Foilseacháin is Déanaí
Nascanna Áisiúil
Téigh i dTeagmháil!
corrado.santocanale@universityofgalway.ie