Dr Janna Luessing
Senior Researcher
Hosted by Noel Lowndes
SFI-IRC Pathway Programme
janna.luessing@universityofgalway.ie

Ábhair Spéise

  • Tuiscint ar na róil atá ag prótéiní sincmhéire sa dheisiú DNA
  • Soléiriú ar na feidhmeanna atá ag cionáisí PIK sa chiticinéis
  • Tréithiú a dhéanamh ar sócháin nádúrtha nua de ATR

Achoimre Taighde

Mutations caused by damage to our genetic material can result in genome instability. These mutations can either be silent and inconsequential or they can lead to cell death or uncontrolled cell growth that is a characteristic of cancer. Our research aims to gain further insights into how cells maintain their genetic stability. Specifically, the focus of my research is to elucidate novel functions for two Zinc finger proteins in DNA repair. These proteins have been previously implicated in intellectual disability and viral infection.

Íomhánna Roghnaithe

Localisation of active ATR throughout the cell cycle. Acitve ATR localises to nuclear speckles in interphase, to centrosomes in mitosis and to the midbody in cytokinesis [Source].
U2OS cells stained with a-53BP1 antibody, EdU Click-IT and DAPI to demonstrate that KIF18B is required for 53BP1 recruitment/retention throughout the cell cycle [Source].
PCR and sequencing of part of the ATR cDNA from patient cells to show exon 18 and exon 28 skipping [Source].

Eochairfhocail

Deisiú DNA, ATR, prótéiní sincmhéire, scoiteadh.

Baill an Ghrúpa

Áine Murphy (PhD)

Croítheichníochatí Taighde

  • Saothrán ceall
  • Micreascóipeacht
  • Bithcheimic prótéine & prótéamaíocht
  • Modhnú géanóim & géanómaíocht

Foilseacháin Roghnaithe

Foilseacháin is Déanaí

Nascanna Áisiúla

Prófíl Ollscoile

PubMed

Google Scholar

Téigh i dTeagmháil!

janna.luessing@universityofgalway.ie